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The researchers meticulously tracked glutathione levels across various cellular compartments to determine true systemic uptake
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
[Abstract]2026 Jan 23
The expression of UGT1A1 is under the control of hepatic nuclear receptors, such as the constitutive androstane receptor (CAR), pregnane X receptor (PXR), glucocorticoid receptor (GR), aryl hydrocarbon receptor (AHR), hepatocyte nuclear receptor 1 (HNR1) [18], and others [14], which regulate UGT1A1 transcription via the hormone response element (HRE) in its promoter [18]
GL: Writing review & editing, Conceptualization, Methodology
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