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When glutathione is depleted, it causes cell death

This is where some background information may be provided, the structure of the AOP is described, and the KEs and KERs are listed

From studies on non-plant organisms we know that the term autophagy includes several mechanisms with the different membrane contributions to build up the phagophore ER being an important starting compartment for this process (Kulich et al., 2013)

10.1016/j.jcis.2018.12.093 10.1016/j.jcis.2018.12.093 [DOI] [PubMed] [Google Scholar] Handy DE, Loscalzo J (2022) The role of glutathione peroxidase-1 in health and disease

James and I didnt want to place undue pressure on the family or on Bobby so we didnt suggest adding any supplements or other steps until the gluten-free diet had been implemented

This effect was postulated to be a result of inhibition of GABA-gated chloride channels, as shown in animal models 194