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Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]

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Trends Pharmacol Sci 20:424429 Miller JS, Barr JL, Harper LJ et al (2014) The GSK3 signaling pathway is activated by cocaine and is critical for cocaine conditioned reward in mice

In mitochondria, the expression of GPx4 was slightly but significantly rescued by ferroptosis inhibitor Fer-1 as well when compared with the single atorvastatin-treated group (Figures 9GJ)

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