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While GLP-1s are not FDA-approved for treating addiction, anecdotal evidence is piling up

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Diabetologia (2012) 55(2):40412.10.1007/s00125-011-2365-4 137 HanSJChoiSEKangYJungJGYiSAKimHJet alEffect of sitagliptin plus metformin on beta-cell function, islet integrity and islet gene expression in Zucker diabetic fatty rats

GLP-1 levels were specifically measured in portal vein plasma 1 hour post-administration, a method chosen to optimize detection of intestinal hormone secretion

This supports a more natural circadian rhythm of GH release

It interacts with neurotransmitter pathways involving serotonin, norepinephrine, and GABA, contributing to its research value in neuroendocrine and circadian rhythm studies