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2b), strongly indicated that this metabolite was wrongly annotated and is instead an adduct of fumarate binding to GSH, which we defined as succinicGSH (Supplementary Fig

The forest plot of meta-analysis odds ratios for colorectal cancer among persons with the MTHFR 677TT and 677CC genotype in Random effects model

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Preparation Condition 4 (EDTA 4 o C deproteinization): Storage at 80 o C prevents enzymatic degradation of GSH We included EDTA-treated plasma stored at 4 o C (Preparation Condition 4) as a positive control for enzymatic processes that may lead to degradation of GSH during sample storage

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