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The staff reviewers said there is insufficient evidence of the safety and efficacy to support allowing compounding pharmacies to manufacture the peptides, citing limited human studies

6 linked pagesOpen original clinicaltrials-bpc157-pco02 Intra-articular injection of BPC 157 for multiple types of knee pain National Library of Medicine Peer reviewed 2021 accessed Jul 12, 2026 Small retrospective, uncontrolled knee-pain report based on telephone follow-up

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The peptide also induces the expression of vascular endothelial growth factor (VEGF) and angiopoietin-1, promoting angiogenesis in injured tissues

Most people tolerate them well, experiencing only mild side effects such as temporary soreness at the injection site or mild headaches

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