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[28] noted that in Bhatta and Glantzs analysis [31], the majority of EC users currently or formerly smoked: only 12 participants out of 17,601 used ECs but had never smoked cigarettes, and none of these 12 developed respiratory symptoms in the PATH waves examined

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However, current smoking habits were associated with increased serum cystatin C levels independent of renal function as a result of unknown mechanisms, 37 which suggests the possibility of underestimation in smokers

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