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Immune checkpoint inhibitors have shown promising results in various GI cancers, particularly in microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) tumors, which are characterized by a high mutational burden and increased immunogenicity

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10.1016/s0166-2236(02)02269-5 39 GerrowK.El-HusseiniA

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No, you can't and shouldn't try to stop melanin production completely