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In fact, changes in GSH levels and/or oxidation state have now been reported in nearly all major human diseases

Apart from possible selenosis caused by excessive Se accumulation, intervention with micronutrient Se in subjects with adequate Se levels failed to reduce the incidence of thyroid cancer ( 4 Se supplementation and precautions The daily intake of Se in human is determined by a combination of the Se value in dietary content, the intake of food and the configuration of the diet

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Nelson, Biochemical Pharmacology, 2013 Glutathione depletion and oxidative stress in acetaminophen-induced liver injury , B

This can cause unnecessary indulgence in other investigations such as autoimmune workup, bone marrow examination, etc., thereby delaying the diagnosis