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Management and investigation of neonatal encephalopathy: 2017 update

A newer finding from Phase 3 data is dysesthesia (skin tingling or sensitivity) affecting about 21% of participants at the highest dose

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It was reported that p53 could promote ferroptosis by repressing the expression of SLC7A11 in both transcriptional and non-transcriptional manners, which led to the decreased uptake of Cys2 and impaired GSH biogenesis[40, 41]