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doi: 10.2337/dc25-SINT NICE

Full cognitive enhancement effectsmemory, learning capacity, stress resiliencetypically develop over 2-4 weeks as neuroplasticity changes accumulate

When a patient loses weight and their blood sugar drops, we adjust their diabetes medication in the same visit

While the medication's core appetite-suppressing and metabolic effects generally persist with continued treatment, some specific effectsparticularly delayed gastric emptyingdo attenuate over time

These range from delayed discomfort with high-intensity exercise and sparring of glycogen during moderate-intensity exercise due to increased fatty acid metabolism

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