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How Isotretinoin Is Processed by the Liver After oral absorption (enhanced by fatty meals), isotretinoin undergoes first-pass metabolism to 4-oxo-isotretinoin and retinoic acid derivatives

GLP-1 medications soften these signals

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Still, plasma GIP secretion in response to duodenal luminal administration occurs earlier than GLP-1 secretion (Roberge and Brubaker, 1993)

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doi: 10.3390/foods14050813, 70 LiangL.LiuZ.YangN.XiaY.WangC.GaoH.et al