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According to protein structure predictions 23 , they also adopt the thioredoxin fold, which puts the putative active site, a CCMC/S or CCLC/S motif, at the beginning of helix 1 (shown exemplarily for ROXY9 in Fig

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Conversely, SIRT3 overexpression has the opposite effects, 105 suggesting that SIRT3 inhibits AKT-dependent mitochondrial metabolism and EMT, thereby promoting ferroptosis

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J Biol Chem 265: 77097712

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