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Dehydration from not drinking enough water is a simple but often overlooked cause

Random tests are typically conducted under DOT regulations for safety-sensitive positions (covered separately below) or under employer-specific policies for non-DOT workplaces

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Melanomas have an abnormal overexpression of tumor-associated antigens (such as MART1/MLANA, MAGE antigens, and NY-ESO1), which makes them vulnerable to T-cell death as T cells that recognize such antigens are able to bypass negative thymic screening

Thompson PJ, Baxendale SA, Duncan JS, Sander JW