ORCID: Affiliation: 13 Department of Biochemistry, Institute of Chemistry, University of So Paulo, Cidade Universitria, So Paulo CEP 05508-000, SP, Brazil 14 International Joint Research Center on Purinergic Signalling, School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China These authors contributed equally to this work
PDA J Pharm Sci Technol
Warfarin is also used to treat or prevent venous thrombosis (swelling and blood clot in a vein) and pulmonary embolism (a blood clot in the lung)
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Experimental work has associated Epithalon with modulation of genes such as: CD5 linked to immune cell differentiation and adaptive immune responses IL-2 involved in T-cell regulation and broader white blood cell signaling MMP2 associated with extracellular matrix remodeling, collagen dynamics, and tissue repair Tram1 related to protein processing and transport Arylalkylamine-N-acetyltransferase (AANAT) a key enzyme in melatonin synthesis pCREB-related targets transcription factors involved in circadian signaling and potentially anti-neoplastic pathways Telomerase-associated components consistent with observations on telomere biology These gene-level interactions position Epithalon as a useful tool compound for studying how small peptides might influence transcriptional regulation in immune, connective, circadian, and genomic-maintenance pathways
Xing, L
