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Some patients respond robustly to lifestyle modifications alone

Future triple agonists targeting GLP-1, GIP, and glucagon receptors simultaneously are in late-stage development at multiple companies and could potentially offer additional efficacy advantages over semaglutide by the late 2020s

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1 However, oral administration of protein/peptide therapeutics has proven difficult due to the harsh conditions of the upper gastrointestinal tract and poor absorption rates in the small intestine

doi: 10.1042/0264-6021:3610417 6 MeyerJKononovSUGrindlerSTrscher-MuotterJAlaedinMFrahmJet al

In other words, the medication may be quieting the very signals that set off a migraine in the first place