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FIGURE 3 3.2.1 -L-glutamyl-4-nitroanilide (GPNA) GPNA, a glutamine analog synthesized by Esslinger, has been widely used to inhibit the glutamine transporter ASCT2 (Esslinger et al., 2005)

At the end of therapeutic process on day 36, all the mice were sacrificed and their right hind ankle joint tissues were obtained

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Besides this, melatonin negatively modulates NF-B and COX-2 signaling, improving overall the therapeutic response [110, 111]