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Animal experiments also provide strong evidence that the ovarian phenotype, including reduced ovulation rate and a dramatic decline in fertility, observed in hyh mutant (Napahyh/hyh) mice is based on an increased rate of apoptosis in GCs and follicular atresia ( Oxidative Stress and Apoptosis in the Ovaries Accumulating evidence shows that oxidative stress is one of the key factors that induces oocyte and GC apoptosis in mammals (Prasad et al., 2016

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