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After 12 d of culture, the ALP activity in the -GP-induced calcifying VSMC group dramatically increased compared to that in the noncalcifying group, while TAU or LC treatment alone had no influence on the ALP activity in the noncalcifying VSMCs

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10.1002/ptr.5026 175 VijayanA

180 In contrast, inhibitors of RHOA, such as ANXA1 which acts via G protein-coupled FPR2 receptors 178,181 and CCM1 or CCM2, stabilize barrier function