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Intranasal RNs significantly improved RGC survival at approximately half the oral dose, thereby minimizing systemic exposure

A., Qiao, J., Jacobson, J

However, in pathological conditions, such as an ischemia or virus infection, astroglial transporters are down-regulated which could lead to excitotoxicity

For vitamin B12, this relatively modest daily requirement reflects the body's efficient recycling mechanisms and the vitamin's storage capacity in the liver, which can maintain reserves for several years (typically 2-5 mg)

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10.1186/s13041-017-0287-x 255 OakleyF