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In the UK, tirzepatide (Mounjaro) is also authorised for weight management in adults with obesity or overweight with weight-related comorbidities, subject to specific eligibility criteria

Patients with chronic kidney disease, those taking nephrotoxic medicines, or those who are pregnant or breastfeeding should avoid creatine

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[ref] Related article : PAI-1 genetic variants MicroRNAs (miRNAs) are short strands of RNA that can bind to mRNA and prevent a gene from being expressed

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Calcium and vitamin D intake, along with regular exercise, can help mitigate this risk