Your body interprets severe caloric restriction as starvation, and it responds by slashing energy expenditure, ramping up cortisol, increasing water retention, and downregulating thyroid function, all of which conspire to halt weight loss despite what looks like a massive calorie deficit on paper
Conclusion Semaglutide injections represent a breakthrough in weight loss therapybut retail prices and insurance hurdles often stand in the way
Hydration and electrolyte balance also matter
Most of this weight loss occurs in the first 32 weeks (9 months) and plateaus, as the body adapts to the medication and patients find a sustainable way of eating
Recognizing Degradation and Communicating with Your Provider Visual inspection offers limited detection of degradation
The STEP trials showed semaglutide producing 14.9% weight loss at 2.4mg weekly