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In particular, it has been demonstrated that Myo-Inositol is the precursor for the synthesis of phosphoinositides, which are part of the phosphatidylinositol (PtdIns) signal transduction pathway
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Additionally, the quantity of proinflammatory cytokines is directly correlated with the accumulation of A plaques in AD, partly due to reduced A clearance as well as increased astrocytic A production [147, 148]
Nonetheless, treatment with rapamycin, a recognized inhibitor of mTOR, induced only a mild extension of lifespan in mice (9% for male and 14% for females) [18]
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