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Triggers the full exercise-adapted gene program: strongly upregulates mitochondrial biogenesis, fatty acid oxidation, oxidative phosphorylation, angiogenesis, and type I (slow-twitch, fatigue-resistant) muscle fiber genes, almost identical to the transcriptional changes seen after endurance training

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These are not theoretical concerns

Additional studies are required to understand shelterin stoichiometries and their functional relevance more broadly

Oxidative stress suppresses phb2mediated mitophagy in cells via the nrf2/phb2 pathway