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When food sits in the stomach longer and you lie down, the stomach contents are more likely to push back up into the esophagus

10.1016/j.mam.2009.01.001 Mol Asp Med

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Interestingly, greater benefits were seen in those with high compared to low homocysteine concentrations at baseline, suggesting the importance of lowering homocysteine levels in prevention of brain atrophy and cognitive decline (91-93)

This step is done for every trial regardless of the phase they are in, in order to find a group of people who can participate in the trial with minimal variations in the results