Nat Rev Cancer
Were trying to figure out which are the GLP-1 receptor populations within the brain that are important for food intake, but that dont produce side effects, Trapp says
SGLT2 inhibitorrelated adverse effects, including genital mycotic infections, volume depletion, and rarely ketoacidosis, remain clinically relevant and should be considered when these agents are prescribed as part of combination therapy and importantly, the intrinsic risk of hypoglycemia with combined GLP-1 receptor agonist and SGLT2 inhibitor therapy is low because neither class directly stimulates insulin secretion in a glucose-independent manner and when hypoglycemia occurs, it is more commonly related to concomitant insulin or sulfonylurea use rather than the combination itself [41, 42, 44]
To our knowledge, the cases herein are the first to demonstrate potential mental health benefits of this next-generation class of drugs, as demonstrated by the GLP-1/GIP receptor agonist tirzepatide
This process helps regulate insulin and glucagon levels, reduce appetite, slow gastric emptying, and promote a feeling of fullness after mealsmaking it easier to manage portions and reduce overall calorie intake
inhibition of lipogenesis
