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10.1158/1535-7163.MCT-09-0290 43 KoeberleA.PollastroF.NorthoffH.WerzO

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Shellfish: Shrimp and oysters are high in zinc and Omega-3 fatty acids

This extension was granted following a thorough review of data submitted by Janssen

Further research found that GA can reverse the decline of peroxisome proliferator-activated receptor alpha (PPAR-) and liver X receptor-alpha (LXR-) and the increase of sterol regulatory element-binding protein-1c (SREBP-1c) mRNA caused by HFD by anti-oxidative stress and improving steatopathy, thus alleviating NAFLD ( GA has the potential to alleviate NAFLD via the AMPK pathway, subsequently hindering the progression to hepatitis and cirrhosis, thereby underscoring AMPK as a crucial therapeutic target

Funding This work was supported by the European Community under Innovative Medicines Initiative (IMI) Program (Grant No