One example, FDA recently approved Lillys KwikPen, which delivers a month of Zepbound GLP-1 in one device
Contribution of central SGK-1 to the acute phase responses of mice to social isolation (in Eng)
In addition to stimulating GLP-1 receptors, it also activates glucose-dependent insulinotropic polypeptide (GIP) receptors, which are involved in both insulin signaling and lipid metabolism (Nauck & DAlessio)
There will be minimal effects on insulin and glucagon production, as both are already significantly impaired in type 1 diabetes, and slowing gastric emptying is not an obvious advantage
Apart from the enhanced activity of fibroblasts, which are pivotal in collagen synthesis, tissue repair, and regeneration, there was also noted a potential rise in mast cell activation
doi: 10.1007/s00394-019-01931-8 149 MohrAEBasileAJMelisaSCSweazeaKLCarpenterKC