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Moreover, exendin-4 inhibits NF-B activity by hindering the breakdown of IB (NF-kappa-B inhibitor alpha) in LPS-stimulated primary microglia, which reduces the activation of microglia and the generation of pro-inflammatory cytokines [113]

Understanding GLP-1: The First Target GLP-1 became the first incretin targeted for pharmaceutical development, leading to medications like exenatide, liraglutide, and eventually semaglutide

GLP-1 receptor agonists, by contrast, include approved medicines with established labels, manufacturing controls, clinical guidance, and postmarketing safety monitoring

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