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Not all medications and nutrients are small enough to get absorbed or need breakdown via gastric enzymes for activation for the sublingual route, but whenever possible there is a benefit to using this route as it bypasses potential damage/absorption issues in the GI tract

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We have previously described a 30% increase in myocardial flow reserve [8] and we speculate that SGLT-2i treatment, by restoring the anti-inflammatory properties of EAT, improves coronary microvascular dysfunction, leading to an amelioration of myocardial flow reserve [9]

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