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Use a protein-first, fiber-smart, hydration-supported, smaller-meal pattern and adjust based on symptoms

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If anxiety occurs, it is more likely during the initial weeks as the body adjusts to the medication

These medications can also cause thyroid tumors in animal studies, although it is still unclear if this risk extends to humans

Resting Energy Expenditure Small-scale indirect calorimetry studies suggest tirzepatide modestly increases resting energy expenditure (REE) beyond what weight loss alone predicts, an effect not consistently seen with liraglutide or semaglutide at approved doses

Synthesis of native proteins by chemical ligation