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The mechanisms underlying semaglutide-related headaches are not fully understood, but several physiological factors may contribute to their occurrence

Declining B12 despite supplementation may indicate an absorption issue requiring higher-dose supplementation

Finally, sometimes, continuing the same medicine becomes impossible because of health changes, such as comorbid conditions

Alternative and complementary approaches to extend treatment benefits Semaglutide works best as part of a comprehensive strategy, not a solo intervention

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Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are alternatives but should be used cautiously in patients with cardiovascular disease, kidney impairment, history of GI ulcers, or those taking anticoagulants