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Future work should also consider not only the end-point genetic changes that occur after bacteria have adapted to the ciprofloxacin environment, but the difference in the evolutionary paths that occur while Zn pre-exposed and Zn nave samples are actively adapting to their antibiotic environment

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110 Mechanistic studies have shown that combination therapy induces increased ROS and lipid peroxides and depletion of GSH, and downregulates ferroptosis inhibitory proteins, including FTH1, SLC7A11, GPX4, and FPN, 110 suggesting that -elemene is a novel inducer of ferroptosis