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Combined with semaglutide (CagriSema), it demonstrated 20.4% weight loss in the Phase 3 REDEFINE 1 trial, approaching the efficacy of bariatric surgery

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In this context, research strategies aimed at the selective inhibition of FOXO proteins including the use of peptide analogs such as FOXO4-DRI represent a promising approach for investigating the modulation of metabolic pathways, with potential relevance to diabetes-related complications

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