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methylphenidate), which increase synaptic dopamine by directly blocking dopamine transporter (DAT)

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2c), indicating a negative charge distribution that promotes repulsion between particles, thereby preventing aggregation

These data showed that Herba Rhodiolae, especially when paired with GSK-3 inhibition, showcases antidepressant properties by orchestrating BDNF/TrkB-GSK-3 signaling and neuroprotective mechanisms (56)

Jakubiak GK, Cielar G, Stanek A, Nitrotyrosine