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Zepbound is a dual GIP and GLP-1 receptor agonist

Mice studies do show that they live longer when given supplemental melatonin over the course of their lives, starting in adulthood.[ref][ref][ref][ref] Animal studies also show that melatonin supplementation (beginning in middle to old age) prevents the decrease in bone mass associated with aging.[ref] It also increases mitochondrial function.[ref] Melatonin is necessary to reap the benefits of exercise when aging.[ref] Supplemental melatonin also doubles insulin sensitivity in older animals.[ref] We dont do human studies on chronic calorie restriction to extend lifespan nor have there been long-term studies in humans on supplemental melatonin for fifty-plus years to know the effect

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Not effective enough for patients with significantly high blood sugar or those who are obese

2025 Aug;15(8):318

thus, mechanistic investigations employing micromolar quantities of free HTY should be considered with this context in mind