16 End-of-dose "wearing off" or deterioration has been related to increasing loss of neuronal storage capability for dopamine
In the literature, it is frequently discussed for its possible role in soft-tissue healing , angiogenic signalling , fibroblast activity , and tendon-related repair processes
NICE guidance (NG100) recommends disease-modifying antirheumatic drugs (DMARDs) as standard care
This might allow for better absorption of both substances without compromising their effectiveness
Indeed, a recent meta-analysis reported that, while proportional to initial loss and varying by type of AOM, weight regain can range from 2.2 kg to 9.7 kg [101]
Clinical studies consistently demonstrate that most patients experience weight regain after stopping these medications