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One effective and common particle in every smoke is carbon monoxide

Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health

This serves two purposes

The film also takes liberty with Bess and Raleigh marrying prior to the Spanish Armada (1588), though in fact the couple married in 1591

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Though most addictive drugs at high doses can cause physiological symptoms that lead to unconsciousness or even death, nicotine is unique in making people physically ill when inhaled or ingested in large quantities