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American Association of Clinical Endocrinology consensus statement on the comprehensive approach to obesity treatment

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The mechanism of action includes stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release , slowing gastric emptying , and acting centrally on the hypothalamus and brainstem to increase satiety and reduce appetite

To gain insight into the molecular mechanism of action of GLP-1 peptides, here we report the crystal structure of the full-length GLP-1 receptor bound to a truncated peptide agonist