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It also plays an essential role in protecting neurons and supporting the immune system, helping to prevent infections and combat complications in cases such as HIV/AIDS and autoimmune diseases

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That discovery launched over four decades of continuous scientific investigation, and what researchers have found since then paints a compelling picture

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Given the multitude of molecules implicated in ferroptosis regulation, we summarize the principal regulators of cellular iron homeostasis and ferroptosis in Table 1, and illustrate the key antioxidant defense pathways relevant to PD in Figure 2