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Published online April 2026

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The oral formulation of semaglutide (Rybelsus) provides an alternative for patients with needle aversion, though it requires specific administration instructionstaken on an empty stomach with no more than 4 ounces of water, at least 30 minutes before any food, beverage, or other oral medications, and swallowed whole

Side effects and safety profiles Safety is where AOD 9604 has its clearest advantage