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This is particularly relevant for patients with pernicious anaemia, where intrinsic factor deficiency prevents adequate oral absorption

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Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations

Structural: Damaged basement membrane allows pigment to drop into the dermis, making topical treatments less effective

Reflecting this, it has been reported that IGF-1 levels are associated with improvements in handgrip strength and physical performance as well as life-span (Birnie et al., 2020)