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Research focuses on the mechanisms that control permeability, including tight junctions, mucus layer integrity, microbial balance, SCFA production, and circadian alignment

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These symptoms can occur in various parts of the body, depending on which nerves are affected

This heterogeneity in treatment responses suggest the existence of underlying determinants both biological and environmental that influence efficacy among patients ( Figure 2 )

For more information, see the Survey Design and Methods Section in the 2011 Report