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Studies comparing GHK (apo) vs GHK-Cu consistently show reduced activity for the copper-free peptide

Rising hunger, waist growth, weight gain above about 2 lb per month, persistent heart-rate elevation, or declining strength indicate that the lower dose is not maintaining the prior response

Nauck MA, Bartels E, rskov C, Ebert R, Creutzfeldt W

According to doctors, the combination of antidepressants and vitamin B12 leads to an improvement in the condition of patients with depression compared to taking medication alone

So, this review aims to summarise the evidence from key studies that addressed this important clinical question

The commonly discussed loading-then-maintenance structure means dosing frequency decreases partway through a protocol, which is different from peptides dosed at a single consistent frequency throughout