Long-term treatment of glucocorticoids is associated with oxidative brain damage in primates, which has been demonstrated (113)
raivokolde/pheatmap
doi: 10.3390/molecules26154601 233 PateiroMGmezBMunekataPESBarbaFJPutnikPKovaeviDBet al
Choosing dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter-2 inhibitors, or both, as add-ons to metformin: patient baseline characteristics are crucial
Recent studies have shown that circulating DPP-4 plays a role in obesity and cardiovascular diseases, and may represent an important molecular link between obesity, diabetes, and cardiovascular disease (Rhrborn et al., 2015)
However, a key challenge is that adherence is often low, which has been related to high costs and side-effects