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Mice deficient in GPR43 exhibit an exacerbated colitis-like phenotype, while administration of SCFAs, including butyrate, ameliorates disease in wild-type but not GPR43-deficient animals, underscoring the receptors essential role in SCFA-mediated intestinal protection (Masui et al., 2013

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As a result, patients often complain about LBP postoperatively with a high recurrence risk of neurological symptoms

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