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Although genetic methods (i.e., gene knockout and knockdown) are powerful approaches, they often activate compensatory pathways, making it difficult to determine the specific role of each enzyme (Zainol et al., 2023)

In REDEFINE 1, which enrolled 3,400 adults without diabetes but with at least one weight-related condition, CagriSema led to an average weight loss of 20.4% at Week 68 , compared to 14.9% with semaglutide, 11.5% with cagrilintide, and 3% with placebo

Subgroup analyses indicated that this risk was particularly elevated in individuals receiving high-dose treatment, in studies of long-acting agents, and in overweight/obese populations

XERF can be an excellent complement to the aesthetic changes that accompany significant weight loss