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In their separate Phase 2 trials, retatrutide monotherapy showed larger weight loss (~24.2% at 48 weeks, 12 mg) than standalone cagrilintide (~10.8% at 26 weeks, 4.5 mg), and indirect network meta-analyses rank retatrutide highly

Increasing Your Dose: Weeks 5-16 Over the next 12 weeks, the dosage is gradually increased every four weeks to reach therapeutic levels while keeping side effects manageable

The effect is dose-dependentmeaning higher doses produce stronger signalsand tends to be most pronounced during the first 24 weeks of treatment or after dose increases

The manufacturer's expiration date is the last point at which they can guarantee the product meets specifications

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